End of the world
I predict that by the time this world comes to an end, no one will be around who cares any more. You have to define "end" anyway. You also have to define "world".
Lets define end as when intelligence looks back and realizes they are not us anymore. Or, end means an abrupt halt to "us".
Lets define world as bags of blood that call themselves human.
With this loose of definitions, the world could end next week and no one who is alive at the time would know.
Nostradamus  said the world ends in a specific year. I bet it is just the last birth certificate that lists the squalling tike as a human.  The world will be populated with genetically modified cybernetic X-Men by then. At least, I hope so. It would be offal boring if things haven't taken some major left tern by then.